import { defineStore } from 'pinia'

export type UserRole = 'sampler' | 'checkPointer'
export type OrderStatus = 'draft' | 'submitted' | 'received' | 'testing' | 'reported' | 'failed'
export type ProductType =
  // 孕前系列
  | 'ECS' | 'ECS-Pro' | 'AZF' | 'Y-Poly'
  // 胚胎植入前系列
  | 'PGT-M' | 'PGT-A' | 'PGT-A-4M' | 'PGT-SR' | 'PGT-MA' | 'PGT-HLA' | 'Array-PGT'
  // 产前系列
  | 'NIPT' | 'NIPT-Plus' | 'CNV-Prenatal' | 'Karyotype' | 'WES-Prenatal' | 'WGS-Prenatal' | 'Array-CGH'
  // 遗传诊断系列
  | 'WES' | 'WGS' | 'BRCA' | 'Panel' | 'CNV-seq' | 'CMA' | 'Methylation' | 'GTV'

export interface Sample {
  id: string
  sampleNo: string
  sampleType: string
  relation: string
  barcode: string
  samplingDate: string
  detectionPlatform?: string
  libraryDate?: string
  sequenceDate?: string
  q30?: number
  duplicate?: number
  readsM?: number
  mapRatio?: number
}

export interface ReportFile {
  id: string
  name: string
  url: string
  date: string
  source?: string
  reviewStatus?: 'pending' | 'approved' | 'rejected'
  geneticNote?: string
  finalNote?: string
  archivedPath?: string
  emailSent?: boolean
}

export interface Order {
  id: string
  orderNo: string
  productType: ProductType
  patientName: string
  hospitalName: string
  submitter: string
  phone: string
  submitDate: string
  status: OrderStatus
  editable: boolean
  hasReport: boolean
  failed: boolean
  failReason?: string
  urgency: boolean
  urgencyReason?: string
  limsStatus: 'pending' | 'pushed' | 'failed'
  samples: Sample[]
  expressNo?: string
  reportFiles?: ReportFile[]
  specialNeeds?: string
  // PGT-M 专属
  femaleAge?: number
  maleAge?: number
  disease?: string
  gene?: string
  inheritMode?: string
  embryoCount?: number
  // 报告邮寄地址
  reportRecipient?: string
  reportPhone?: string
  reportAddress?: string
  reportEmail?: string
}

export interface BioinfoRun {
  id: string
  groupName: string
  appType: 'PGS' | 'PGD' | 'AZF' | 'ECS' | 'Array-PGT'
  status: 'ready' | 'running' | 'success' | 'failed'
  createDate: string
  orderId: string
  notifyLims?: boolean
  results?: {
    chromosome?: string
    cnvConclusion?: string
    aneuploidyConclusion?: string
    q30?: number
    clusterPf?: number
    duplicate?: number
  }
}

export interface Patient {
  id: string
  name: string
  idCard?: string
  phone?: string
  gender?: string
  hospitalName?: string
  // 夫妻信息（PGT系列）
  spouseName?: string
  femaleAge?: number
  maleAge?: number
  // 遗传背景（PGT-M复用）
  disease?: string
  gene?: string
  inheritMode?: string
  knownVariant?: string
  childStatus?: string
  hpoTerms?: string[]
  // 历史
  orderIds: string[]
  lastOrderDate?: string
  lastProductType?: string
  createdAt: string
}

export interface BatchOrder {
  id: string
  name: string
  productType: ProductType
  hospital: string
  region: string
  createDate: string
  status: 'draft' | 'submitted' | 'reviewed'
  orderCount: number
}

export const usePGXStore = defineStore('pgx', () => {
  const currentRole = ref<UserRole>('sampler')

  const orders = ref<Order[]>([
    {
      id: '1', orderNo: 'JB2026030001', productType: 'PGT-M',
      patientName: '张晓华', hospitalName: '北京协和医院',
      submitter: '王医生', phone: '13800138001',
      submitDate: '2026-03-01', status: 'reported',
      editable: false, hasReport: true, failed: false, urgency: false,
      limsStatus: 'pushed', femaleAge: 32, maleAge: 35,
      disease: '脊髓性肌萎缩症(SMA)', gene: 'SMN1',
      inheritMode: '常染色体隐性遗传', embryoCount: 4,
      samples: [
        { id: 's1', sampleNo: 'S001', sampleType: '外周血', relation: '女方', barcode: 'BC2026030001', samplingDate: '2026-02-28', detectionPlatform: 'Illumina', q30: 91.2, duplicate: 12.3, readsM: 15.6, mapRatio: 98.5 },
        { id: 's2', sampleNo: 'S002', sampleType: '外周血', relation: '男方', barcode: 'BC2026030002', samplingDate: '2026-02-28', detectionPlatform: 'Illumina', q30: 92.1, duplicate: 11.8, readsM: 14.9, mapRatio: 99.1 },
        { id: 's3', sampleNo: 'S003', sampleType: '活检样本', relation: '胚胎1', barcode: 'BC2026030003', samplingDate: '2026-02-28', q30: 88.5, duplicate: 15.2, readsM: 10.2, mapRatio: 97.3 },
        { id: 's4', sampleNo: 'S004', sampleType: '活检样本', relation: '胚胎2', barcode: 'BC2026030004', samplingDate: '2026-02-28', q30: 89.3, duplicate: 14.1, readsM: 11.1, mapRatio: 98.0 },
      ],
      expressNo: 'SF1234567890',
      reportFiles: [
        { id: 'r1', name: 'PGT-M报告_张晓华_v1.pdf', url: '#', date: '2026-03-25', source: '生信平台', reviewStatus: 'approved', emailSent: true, archivedPath: '/reports/2026/03/JB2026030001.pdf' }
      ],
      reportRecipient: '王医生', reportPhone: '13800138001', reportEmail: 'wang@pumch.cn'
    },
    {
      id: '2', orderNo: 'JB2026030002', productType: 'PGT-A',
      patientName: '李美丽', hospitalName: '上海妇产科医院',
      submitter: '陈医生', phone: '13900139002',
      submitDate: '2026-03-05', status: 'testing',
      editable: false, hasReport: false, failed: false, urgency: true,
      urgencyReason: '移植周期临近，请加急处理',
      limsStatus: 'pushed', femaleAge: 38,
      samples: [
        { id: 's5', sampleNo: 'S005', sampleType: '活检样本', relation: '胚胎1', barcode: 'BC2026030005', samplingDate: '2026-03-04', detectionPlatform: 'Illumina', q30: 87.2, duplicate: 16.5, readsM: 9.8, mapRatio: 96.8 },
        { id: 's6', sampleNo: 'S006', sampleType: '活检样本', relation: '胚胎2', barcode: 'BC2026030006', samplingDate: '2026-03-04', q30: 90.1, duplicate: 13.2, readsM: 12.3, mapRatio: 98.2 },
        { id: 's7', sampleNo: 'S007', sampleType: '活检样本', relation: '胚胎3', barcode: 'BC2026030007', samplingDate: '2026-03-04' },
      ]
    },
    {
      id: '3', orderNo: 'JB2026030003', productType: 'ECS',
      patientName: '刘婷婷', hospitalName: '广州市妇女儿童医疗中心',
      submitter: '刘医生', phone: '13700137003',
      submitDate: '2026-03-10', status: 'received',
      editable: false, hasReport: false, failed: false, urgency: false,
      limsStatus: 'pushed',
      samples: [
        { id: 's8', sampleNo: 'S008', sampleType: '外周血', relation: '女方', barcode: 'BC2026030008', samplingDate: '2026-03-09' },
      ]
    },
    {
      id: '4', orderNo: 'JB2026030004', productType: 'WES',
      patientName: '赵小明', hospitalName: '北京儿童医院',
      submitter: '赵医生', phone: '13600136004',
      submitDate: '2026-03-15', status: 'failed',
      editable: false, hasReport: false, failed: true,
      failReason: '样本量不足，DNA提取失败，请重新采集样本',
      urgency: false,
      limsStatus: 'pushed',
      samples: [
        { id: 's9', sampleNo: 'S009', sampleType: '外周血', relation: '先证者', barcode: 'BC2026030009', samplingDate: '2026-03-14' },
      ]
    },
    {
      id: '5', orderNo: 'JB2026030005', productType: 'PGT-M',
      patientName: '孙雅丽', hospitalName: '复旦大学附属妇产科医院',
      submitter: '孙医生', phone: '13500135005',
      submitDate: '2026-03-20', status: 'submitted',
      editable: false, hasReport: false, failed: false, urgency: true,
      urgencyReason: '患者情况特殊，请优先处理',
      limsStatus: 'pending',
      samples: [
        { id: 's10', sampleNo: 'S010', sampleType: '外周血', relation: '女方', barcode: 'BC2026030010', samplingDate: '2026-03-19' },
        { id: 's11', sampleNo: 'S011', sampleType: '外周血', relation: '男方', barcode: 'BC2026030011', samplingDate: '2026-03-19' },
      ]
    },
    {
      id: '6', orderNo: 'JB2026030006', productType: 'AZF',
      patientName: '周建国', hospitalName: '中山大学附属第一医院',
      submitter: '周医生', phone: '13400134006',
      submitDate: '2026-03-25', status: 'draft',
      editable: true, hasReport: false, failed: false, urgency: false,
      limsStatus: 'pending',
      samples: []
    },
    {
      id: '7', orderNo: 'JB2026030007', productType: 'BRCA',
      patientName: '吴小红', hospitalName: '中国医学科学院肿瘤医院',
      submitter: '吴医生', phone: '13300133007',
      submitDate: '2026-03-28', status: 'submitted',
      editable: false, hasReport: false, failed: false, urgency: false,
      limsStatus: 'pushed',
      samples: [
        { id: 's12', sampleNo: 'S012', sampleType: '外周血', relation: '先证者', barcode: 'BC2026030012', samplingDate: '2026-03-27' },
      ]
    },
  ])

  const bioinfoRuns = ref<BioinfoRun[]>([
    { id: 'b1', groupName: '张晓华-PGT-M-20260302', appType: 'PGD', status: 'success', createDate: '2026-03-02', orderId: '1', notifyLims: true, results: { cnvConclusion: '胚胎1:整倍体,胚胎2:整倍体', q30: 91.2, clusterPf: 95.3, duplicate: 12.3 } },
    { id: 'b2', groupName: '李美丽-PGT-A-20260306', appType: 'PGS', status: 'running', createDate: '2026-03-06', orderId: '2', results: { q30: 87.2, clusterPf: 93.1, duplicate: 16.5 } },
    { id: 'b3', groupName: '刘婷婷-ECS-20260311', appType: 'ECS', status: 'ready', createDate: '2026-03-11', orderId: '3' },
    { id: 'b4', groupName: '赵小明-WES-20260316', appType: 'PGS', status: 'failed', createDate: '2026-03-16', orderId: '4' },
  ])

  const patients = ref<Patient[]>([
    {
      id: 'p1', name: '张晓华', phone: '13800138001', gender: '女', hospitalName: '北京协和医院',
      femaleAge: 32, maleAge: 35, spouseName: '张某某',
      disease: '脊髓性肌萎缩症(SMA)', gene: 'SMN1', inheritMode: '常染色体隐性遗传',
      knownVariant: 'del exon 7-8', childStatus: '有先证者在世',
      hpoTerms: ['HP:0002011', 'HP:0001324'],
      orderIds: ['1'], lastOrderDate: '2026-03-01', lastProductType: 'PGT-M',
      createdAt: '2026-03-01',
    },
    {
      id: 'p2', name: '李美丽', phone: '13900139002', gender: '女', hospitalName: '上海妇产科医院',
      femaleAge: 38, maleAge: 40,
      orderIds: ['2'], lastOrderDate: '2026-03-05', lastProductType: 'PGT-A',
      createdAt: '2026-03-05',
    },
    {
      id: 'p3', name: '刘婷婷', phone: '13700137003', gender: '女', hospitalName: '广州市妇女儿童医疗中心',
      femaleAge: 29,
      orderIds: ['3'], lastOrderDate: '2026-03-10', lastProductType: 'ECS',
      createdAt: '2026-03-10',
    },
    {
      id: 'p4', name: '孙雅丽', phone: '13500135005', gender: '女', hospitalName: '复旦大学附属妇产科医院',
      femaleAge: 33, maleAge: 36,
      disease: '地中海贫血', gene: 'HBB', inheritMode: '常染色体隐性遗传',
      orderIds: ['5'], lastOrderDate: '2026-03-20', lastProductType: 'PGT-M',
      createdAt: '2026-03-20',
    },
    {
      id: 'p5', name: '吴小红', phone: '13300133007', gender: '女', hospitalName: '中国医学科学院肿瘤医院',
      femaleAge: 42,
      orderIds: ['7'], lastOrderDate: '2026-03-28', lastProductType: 'BRCA',
      createdAt: '2026-03-28',
    },
  ])

  const batchOrders = ref<BatchOrder[]>([
    { id: 'bt1', name: '协和医院-3月批次', productType: 'PGT-A', hospital: '北京协和医院', region: '华北', createDate: '2026-03-01', status: 'reviewed', orderCount: 12 },
    { id: 'bt2', name: '上海妇产-PGT-M批次', productType: 'PGT-M', hospital: '上海妇产科医院', region: '华东', createDate: '2026-03-10', status: 'submitted', orderCount: 8 },
    { id: 'bt3', name: '广州妇儿-ECS筛查', productType: 'ECS', hospital: '广州市妇女儿童医疗中心', region: '华南', createDate: '2026-03-20', status: 'draft', orderCount: 5 },
  ])

  // 计算属性
  const draftOrders = computed(() => orders.value.filter(o => o.status === 'draft'))
  const submittedOrders = computed(() => orders.value.filter(o => o.status === 'submitted'))
  const receivedOrders = computed(() => orders.value.filter(o => o.status === 'received'))
  const testingOrders = computed(() => orders.value.filter(o => o.status === 'testing'))
  const reportedOrders = computed(() => orders.value.filter(o => o.status === 'reported' && o.hasReport))
  const failedOrders = computed(() => orders.value.filter(o => o.failed))

  const stats = computed(() => ({
    total: orders.value.length,
    draft: draftOrders.value.length,
    submitted: submittedOrders.value.length,
    received: receivedOrders.value.length,
    testing: testingOrders.value.length,
    reported: reportedOrders.value.length,
    failed: failedOrders.value.length,
    limsError: orders.value.filter(o => o.limsStatus === 'failed').length,
  }))

  function switchRole(role: UserRole) { currentRole.value = role }

  function addOrder(order: Omit<Order, 'id'>) {
    const newOrder = { ...order, id: Date.now().toString() }
    orders.value.unshift(newOrder as Order)
    return newOrder
  }

  function updateOrder(id: string, updates: Partial<Order>) {
    const idx = orders.value.findIndex(o => o.id === id)
    if (idx !== -1) orders.value[idx] = { ...orders.value[idx], ...updates }
  }

  function submitOrder(id: string) {
    updateOrder(id, { status: 'submitted', editable: false, limsStatus: 'pushed' })
  }

  function receiveOrder(id: string) {
    updateOrder(id, { status: 'received' })
  }

  function deleteOrder(id: string) {
    const idx = orders.value.findIndex(o => o.id === id)
    if (idx !== -1) orders.value.splice(idx, 1)
  }

  function addBioRun(run: Omit<BioinfoRun, 'id'>) {
    const newRun = { ...run, id: 'b' + Date.now() }
    bioinfoRuns.value.unshift(newRun as BioinfoRun)
    return newRun
  }

  function updateBioRun(id: string, updates: Partial<BioinfoRun>) {
    const idx = bioinfoRuns.value.findIndex(r => r.id === id)
    if (idx !== -1) bioinfoRuns.value[idx] = { ...bioinfoRuns.value[idx], ...updates }
  }

  function getOrderById(id: string) {
    return orders.value.find(o => o.id === id)
  }

  function searchPatients(keyword: string): Patient[] {
    if (!keyword) return patients.value.slice(0, 8)
    const kw = keyword.toLowerCase()
    return patients.value.filter(p =>
      p.name.includes(keyword) ||
      p.phone?.includes(keyword) ||
      p.idCard?.includes(keyword)
    ).slice(0, 10)
  }

  function upsertPatient(data: Partial<Patient> & { name: string }, orderId: string) {
    const existing = patients.value.find(p => p.name === data.name && p.phone === data.phone)
    if (existing) {
      existing.orderIds.push(orderId)
      existing.lastOrderDate = data.lastOrderDate || new Date().toISOString().split('T')[0]
      existing.lastProductType = data.lastProductType
      // 更新可能变化的字段
      if (data.femaleAge) existing.femaleAge = data.femaleAge
      if (data.hospitalName) existing.hospitalName = data.hospitalName
      if (data.disease) existing.disease = data.disease
      if (data.gene) existing.gene = data.gene
    } else {
      patients.value.unshift({
        id: 'p' + Date.now(),
        name: data.name,
        phone: data.phone,
        gender: data.gender,
        hospitalName: data.hospitalName,
        femaleAge: data.femaleAge,
        maleAge: data.maleAge,
        spouseName: data.spouseName,
        disease: data.disease,
        gene: data.gene,
        inheritMode: data.inheritMode,
        knownVariant: data.knownVariant,
        childStatus: data.childStatus,
        hpoTerms: data.hpoTerms,
        orderIds: [orderId],
        lastOrderDate: new Date().toISOString().split('T')[0],
        lastProductType: data.lastProductType,
        createdAt: new Date().toISOString().split('T')[0],
      })
    }
  }

  function addReportFile(orderId: string, file: ReportFile) {
    const order = getOrderById(orderId)
    if (order) {
      if (!order.reportFiles) order.reportFiles = []
      order.reportFiles.push(file)
      updateOrder(orderId, { hasReport: true, status: 'reported', reportFiles: order.reportFiles })
    }
  }

  return {
    currentRole, orders, bioinfoRuns, batchOrders,
    draftOrders, submittedOrders, receivedOrders, testingOrders, reportedOrders, failedOrders, stats,
    switchRole, addOrder, updateOrder, submitOrder, receiveOrder, deleteOrder,
    addBioRun, updateBioRun, getOrderById, addReportFile,
    patients, searchPatients, upsertPatient
  }
})